Kayexalate mechanism of action

KAYEXALATE Monographs. Sodium polystyrene sulfonate is a cation-exchange resin used in the treatment of hyperkalemia. Each gram of resin will remove roughly 3 mEq of potassium in vitro, but because sodium polystyrene sulfonate can bind other cations, the actual amount of potassium removed in vivo is closer to 1 mEq per gram of drug.

Diuretics are drugs that primarily increase the excretion of sodium. To some extent, they also increase the volume of urine produced by the kidneys. By blocking the absorptive capacity of cells lining the renal tubules for sodium, intravascular volume and the eventual leaking of fluid from capillaries is reduced and prevented. It is used in the management of diseases like glaucoma ...
The future of hyperkalemia: Beyond Kayexalate When to Refer to Nephrology Questions Your question is our question 3 4. 11/3/2019 3 overview ... Mechanism Of Action GLP-1 Receptor Agonists Mechanism Of Action 17 18. 11/3/2019 10 GLP-1 Receptor Agonists Glucagon-like Peptide Agonists ELIXA TRIAL LEADER TRIAL Liraglutide
CLINICAL PHARMACOLOGY Mechanism Of Action. KAYEXALATE is a non-absorbed, cation exchange polymer that contains a sodium counterion. KAYEXALATE increases fecal potassium excretion through binding of potassium in the lumen of the gastrointestinal tract.Binding of potassium reduces the concentration of free potassium in the gastrointestinal lumen, resulting in a reduction of serum potassium levels.
Thiazide diuretics tend to have only a weak action on the kidneys so you don't notice a great increase in urine if you take these (compared with loop diuretics). They also have the effect of widening (dilating) blood vessels. A combination of these two effects reduces the blood pressure.
headache. inability to have or keep an erection. itching skin. loss in sexual ability, desire, drive, or performance. menstrual changes. nausea and vomiting. stopping of menstrual bleeding. Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Onset of action 2-24 hours. Powder: to give orally or by NG/NJ, mix with 3-4 mL water or D5W or D10W per gram of powder. To give rectally, mix to a concentration of 0.3-0.5 gram/mL with D5W. Do not give sorbitol suspension rectally. Retain enema in colon for at least 30-60 min., several hours if possible.
The future of hyperkalemia: Beyond Kayexalate When to Refer to Nephrology Questions Your question is our question 3 4. 11/3/2019 3 overview ... Mechanism Of Action GLP-1 Receptor Agonists Mechanism Of Action 17 18. 11/3/2019 10 GLP-1 Receptor Agonists Glucagon-like Peptide Agonists ELIXA TRIAL LEADER TRIAL Liraglutide
Mechanism of action Cautions; Calcium gluconate. ... (Kayexalate), which binds potassium in the colon in exchange for sodium; it can be given orally or as a retention enema. The enema form is ...
One gram of KAYEXALATE contains 4.1 mEq of sodium. 12 CLINICAL PHARMACOLOGY . 12.1 Mechanism of Action . KAYEXALATE is a non-absorbed, cation exchange polymer that contains a sodium counterion....
Hyperkalemia, used to describe an elevated level of potassium in the blood, occurs when there is a disturbance in the balance between intake and elimination or a shift of potassium between the intracellular and extracellular spaces. Eighty percent to 90% of potassium is eliminated renally. Therefore, patients with kidney disease are most at ...
Management of Elevated INRs. Increase or decrease oral Vitamin K administration based on the clinical situation. Parenteral Vitamin K should only be used for life-threatening bleeding and is therefore not appropriate for outpatient use. Use the recommendations for the next lower INR range in the following situations:
Harel Z, Harel S, Shah PS, et al. Gastrointestinal adverse events with sodium polystyrene sulfonate (Kayexalate) use: a systematic review. Am J Med 2013;126(3):264.e9-264.e24. Google Scholar